Citation

Stellpflug SJ, Fritzlar SJ, Cole JB, Engebretsen KM, Holger JS. J. Med. Toxicol. 2011; 7(2): 151-153.

Copyright

(Copyright © 2011, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s13181-010-0133-3

PMID

21174185

PMCID

PMC3724444

Abstract

High-dose insulin (HDI) and intravenous fat emulsion (IFE) are used in overdoses, although rarely combined. To our knowledge, IFE therapy has not been reported in overdoses of diltiazem, metoprolol and amiodarone. We report a severe overdose of these drugs treated with HDI and IFE in a patient with hypertrophic cardiomyopathy (HCM). We also discuss the potential clinical implications of the inotropic effects of HDI in the setting of HCM and the use and efficacy of IFE in this overdose.

Language: en

Keywords

Humans; Adult; Female; Drug Overdose; Treatment Outcome; Suicide, Attempted; Hypoglycemic Agents; Insulin; Drug Therapy, Combination; Dose-Response Relationship, Drug; Amiodarone; Fat Emulsions, Intravenous; Cardiomyopathy, Hypertrophic; Cardiotoxins; Diltiazem; Adrenergic beta-1 Receptor Antagonists; Metoprolol