Citation

Machado RA, Espinosa AG, Montoto AP. Epilepsy Behav. 2010; 19(3): 509-512.

Copyright

(Copyright © 2010, Elsevier Publishing)

DOI

10.1016/j.yebeh.2010.06.045

PMID

20888305

Abstract

OBJECTIVE: Low cholesterol levels are associated with depression and suicide in persons with epilepsy. The goal of this study was to determine whether plasma cholesterol concentration is a predictor of response to sertraline.
METHODS: We carried out a prospective open-label study on the efficacy of sertraline as therapy in the treatment of depressive disorder in patients with mesial temporal lobe epilepsy. Patients were treated for 24 weeks at dose levels between 50 and 100mg/day. All patients were evaluated at the beginning of the investigation and 6 months later by two psychiatrists using a structured interview.
RESULTS: The mean total cholesterol concentration of nonresponding patients was lower than the mean (SD) cholesterol level of responders [3.2 (0.9) mmol/L vs 5.2 (1.5) mmol/L]; this difference reached statistical significance (P = 0.0000). We found a negative correlation between scores on the Hamilton scale and cholesterol concentrations (r = -33).
CONCLUSION: The response to sertraline may depend on the baseline cholesterol concentration.

Language: en

Keywords

Humans; Adult; Female; Male; Middle Aged; Suicide, Attempted; Follow-Up Studies; Linear Models; Dose-Response Relationship, Drug; Depressive Disorder; Cholesterol; Sertraline; Selective Serotonin Reuptake Inhibitors; Epilepsy, Temporal Lobe