Citation

Koleva HK, Erickson MA, Vanderlip ER, Tansey J, Mac J, Fiedorowicz JG. Ann. Clin. Psychiatry 2009; 21(2): 77-80.

Copyright

(Copyright © 2009, American Academy of Clinical Psychiatrists)

DOI

unavailable

PMID

19439156

PMCID

PMC3043556

Abstract

BACKGROUND: Edema associated with quetiapine has been described in only one case report to date and represents a potentially serious adverse reaction.
METHODS: We present a case series of 3 patients who developed bilateral leg edema following initiation of quetiapine.
RESULTS: One of these patients had a recurrence of edema with subsequent rechallenge. Another patient developed quetiapine-induced edema following a prior episode of olanzapine-induced edema. All 3 cases present a compelling temporal relationship between the drug challenge and the adverse event.
CONCLUSION: Prompt recognition and intervention with discontinuation of the offending agent is important for this potentially serious, seemingly idiosyncratic vascular complication.

Language: en

Keywords

Adult; Antipsychotic Agents; Bipolar Disorder; Depression; Dibenzothiazepines; Drug Administration Schedule; Edema; Female; Humans; Middle Aged; Psychomotor Agitation; Quetiapine Fumarate; Suicide, Attempted