Citation

Weng SF, Hung DZ, Hu SY, Tsan YT, Wang LM. Clin. Toxicol. (Phila) 2008; 46(9): 890-891.

Copyright

(Copyright © 2008, Informa - Taylor and Francis Group)

DOI

10.1080/15563650802286731

PMID

18787996

Abstract

INTRODUCTION: Glyphosate-surfactant herbicide (GlySH) is widely used as a non-selective herbicide. Most intoxicated cases are from ingestion, inhalation, and skin exposure. Intramuscular injection of GlySH has never been reported. We present a case of GlySH intoxication via intramuscular injection.
CASE REPORT: A 42-year-old woman came to the emergency department complaining of painful swelling of left upper limb for 12 h. She had performed an intramuscular injection of 6 mL of GlySH over the lateral aspect of the left elbow 15 h previously. Physical examination disclosed painful swelling over left distal arm, elbow, and forearm with three needle punctures. CT scan revealed ill-defined areas of heterogeneous high density with marked swelling at subcutaneous tissue over posterior aspect of the elbow.
DISCUSSION: The mechanism of toxicity of GlySH is complicated and surfactant was thought to play an important role in GlySH intoxication. Intramuscular GlySH poisoning is different from oral GlySH intoxication. Care should be taken when monitoring acute rhabdomyolysis and compartment syndrome, which may develop rapidly and contribute to the surfactant component of glyphosate formulation.

Language: en

Keywords

Adult; Female; Glycine; Glyphosate; Herbicides; Humans; Injections, Intramuscular; Rhabdomyolysis; Suicide, Attempted; Surface-Active Agents