Citation

Sabbe MB, Desruelles D, Lissens W. Hum. Exp. Toxicol. 2008; 27(5): 431-433.

Copyright

(Copyright © 2008, SAGE Publishing)

DOI

10.1177/0960327108094614

PMID

18715890

Abstract

beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that beta-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans.

Language: en

Keywords

Acetylcholinesterase; Atropine; Biomarkers; Cholinesterase Inhibitors; Drug Therapy, Combination; Fluid Therapy; Glucuronidase; Humans; Male; Middle Aged; Obidoxime Chloride; Parathion; Poisoning; Propofol; Suicide, Attempted; Vasoconstrictor Agents