Citation

Galea M, Jelacin N, Bramham K, White I. Br. J. Anaesth. 2007; 98(2): 213-215.

Copyright

(Copyright © 2007, Oxford University Press)

DOI

10.1093/bja/ael347

PMID

17251212

Abstract

We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril. The lactic acidosis was successfully treated with early high-volume continuous veno-venous haemofiltration. Rhabdomyolysis and lower limb compartment syndrome developed later. The patient otherwise made a good recovery. We discuss the management of severe lactic acidosis secondary to metformin overdose and the association with rhabdomyolysis.

Language: en

Keywords

Acidosis, Lactic; Antihypertensive Agents; Compartment Syndromes; Drug Overdose; Hemofiltration; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Ramipril; Rhabdomyolysis; Suicide, Attempted