Citation

Ferreira Maia AP, Boarati MA, Kleinman A, Fu-I L. J. Affect. Disord. 2007; 104(1-3): 237-243.

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

10.1016/j.jad.2007.04.003

PMID

17512606

Abstract

OBJECTIVE: This study describes the clinical phenomenology and family history of preschool age onset Bipolar Disorder (BD).
METHODS: Eight children and adolescents out of 118 cases (6.78%), both genders, meeting current DSM-IV criteria diagnosis of BD were described. The clinical assessment, CBCL, DICA-IV and CGAS were performed directly with each patient and their parents.
RESULTS: Most (87.5%) presented classical symptoms of mania: euphoria, grandiosity, irritability, psychomotor agitation and agitated sleep or, in the same proportion, sleeplessness. Hyperactivity and increase of energy were found in all eight cases. The clinical course varied from a rapid, ultra-rapid, ultradian cycle to a continued pattern. Five out of eight children (62.5%) presented aggressiveness toward others and one deliberate self-harm. Most (87.5%) had psychiatric family history. The average number of medications used during their life was 4.5 drugs.
LIMITATION: The small sample and retrospective reports of the first manic symptoms in three of the cases (cases V, VI and VII).
CONCLUSION: An important incidence of classical manic features was found in very young children. The clinical course tended to be continuous, and preschool BD seems to have a strong association with affective disorder family history.

Language: en

Keywords

Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Brazil; Central Nervous System Stimulants; Child; Child, Preschool; Female; Humans; Male