Citation

Rafai MA, Boulaajaj FZ, Charra B, Benslama A, Motaouakkil S, Slassi I. Rev. Neurol. (Masson) 2007; 163(4): 480-482.

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

10.1016/s0035-3787(07)90425-7

PMID

17452951

Abstract

Acute organophosphate poisoning, whether accidental or suicidal, is frequent in developing countries and produces significant morbidity and mortality. Organophosphates inhibit cholinesterase activity at the neuromuscular junction and cause extensive muscle paralysis, particularly for respiratory function. Poisonings evolve in three stages: cholinesterase crisis, intermediate syndrome and delayed neuropathy. Electrophysiological aspects have been poorly studied. We report the case of a 25-year-old woman admitted to intensive care unit with muscarinic signs and respiratory failure after attempted suicidal organophosphate poisoning. Cholinesterase activity was low and the electrophysiological study disclosed the characteristic aspect of intermediate syndrome. The patient died due to septic complications. This syndrome is exceptional with a poorly understood pathophysiology. The electrophysiological study is essential for diagnosis.

Language: fr

Keywords

Adult; Cholinesterase Inhibitors; Cholinesterases; Electric Stimulation; Electrodiagnosis; Electrophysiology; Fatal Outcome; Female; Humans; Median Nerve; Organophosphate Poisoning; Sepsis; Suicide, Attempted