Citation

Diedler J, Mellado P, Veltkamp R. J. Neurol. Sci. 2008; 264(1-2): 163-165.

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.jns.2007.06.052

PMID

17706678

Abstract

We report a case of severe neuroleptic malignant syndrome with hyperthermia, rhabdomyolysis and hepatic failure where we applied endovascular cooling in order to reverse hyperthermia. After rapid normalization of core temperature at 37.5 degrees C, the patient's condition improved and CK levels dropped. However, upon withdrawl of endovascular temperature control there was a relapse. This is the first case where endovascular cooling was applied successfully in neuroleptic malignant syndrome.

Language: en

Keywords

Antipsychotic Agents; Catheters, Indwelling; Creatine Kinase; Drug Synergism; Female; Fever; Haloperidol; Histamine H1 Antagonists; Humans; Hypothermia, Induced; Liver Failure, Acute; Middle Aged; Neuroleptic Malignant Syndrome; Promethazine; Recurrence; Rhabdomyolysis; Suicide, Attempted; Treatment Outcome