Citation

Inoue S, Yamamoto I, Akieda K, Sekiguchi H, Otuka H, Morita S, Nakagawa Y, Inokuchi S. Chudoku Kenkyu 2006; 19(3): 265-271.

Copyright

(Copyright © 2006, Yakugyo Jihosha)

DOI

unavailable

PMID

16922458

Abstract

A 41-year-old female attempted suicide by taking 7.8g acetaminophen and was transferred to our hospital four hours after ingestion. The patient was diagnosed as non-hepatic toxicity (below the line set by the Rumack Matthew nomogram). Laboratory data showed an elevation in serum liver enzymes and coagulation defects at 3 days after ingestion, therefore, the patient was treated with plasma exchange and an oral administration of N-acetylcysteine (NAC). The elevation of liver enzymes was maximal at 4 days after ingestion, and the laboratory data became normalized at approximately 9 days after ingestion. In this case, habitual alcohol intake may have exacerbated the severe liver injury. We should consider an exacerbation of hepatotoxicity and administer NAC in any case having a history of habitual alcohol intake, even if the case was diagnosed as non-hepatic toxicity by the nomogram.

Language: ja

Keywords

Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Diseases; Plasma Exchange; Severity of Illness Index; Suicide, Attempted; Therapeutics