Citation

Chen TJ, Yu YWY, Chen MC, Wang SY, Tsai SJ, Lee TW. Neuropsychobiology 2005; 52(1): 28-36.

Copyright

(Copyright © 2005, Karger Publishers)

DOI

10.1159/000086175

PMID

15942261

Abstract

BACKGROUND: Serotonergic dysfunction is believed to be involved in suicide attempts. The loudness-dependent auditory evoked potential (LDAEP) is one of the validated indicators of the activity of the central serotonin system in humans.
OBJECTIVES: This study was designed to investigate possible differences in the LDAEP and P300 between those depressed patients who attempted suicide and those who did not.
METHODS: The LDAEP and P300 levels were recorded for 66 depressive patients (among which 16 had attempted suicide).
RESULTS: Those who had attempted suicide showed a sharper slope of the LDAEP and increased frontal P300 amplitude. A high correlation between the LDAEP and P300, and a gender difference were also noted.
CONCLUSIONS: Our results are concordant with previous assumptions about serotonin dysfunction in depressives who attempt suicide.

Language: en

Keywords

Adult; Depressive Disorder, Major; Electroencephalography; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Humans; Linear Models; Male; Psychiatric Status Rating Scales; Serotonin; Suicide, Attempted