Citation

Aouate P, Clerc J, Viard P, Seoud J. J. Cardiovasc. Electrophysiol. 2005; 16(3): 348-351.

Copyright

(Copyright © 2005, John Wiley and Sons)

DOI

10.1046/j.1540-8167.2005.40564.x

PMID

15817098

Abstract

This is the first report of Brugada syndrome revealed by beta-blocker intoxication. A 24-year-old healthy man ingested propranolol (2.28 g) to commit suicide. After early gastric lavage, electrolytes, cardiac enzymes, chest X-ray, and echocardiography were normal. Dosages of psychotropic drugs were negative. ECG showed a typical coved-type pattern of Brugada syndrome. Follow-up showed partial ECG normalization of the discrete saddleback-type pattern. The ajmaline- test confirmed Brugada syndrome. These ECG modifications may be explained by the stabilizing membrane effect of high concentration of propranolol and/or inhibition of ICaL. This case illustrates the possible deleterious effects of beta-blockers in patients with Brugada syndrome.

Language: en

Keywords

Adrenergic beta-Antagonists; Adult; Atropine; Bundle-Branch Block; Death, Sudden, Cardiac; Electrocardiography; Glucagon; Humans; Male; Propranolol; Suicide, Attempted; Syndrome; Ventricular Fibrillation