Citation

Wood DM, Wright KD, Jones AL, Dargan PI. Hum. Exp. Toxicol. 2005; 24(7): 377-381.

Copyright

(Copyright © 2005, SAGE Publishing)

DOI

10.1191/0960327105ht538oa

PMID

16119252

Abstract

OBJECTIVE: To report a patient with a significant amlodipine self-poisoning who failed to clinically respond to conventional treatment and was managed with metaraminol (Aramine).
PATIENT: A 43-year old male presenting after ingestion of 560 mg amlodipine, who failed to respond clinically to treatment with fluid resuscitation, calcium salts, glucagon and norepinephrine/epinephrine inotropic support.
MAIN RESULTS: Following a loading bolus of 2 mg and intravenous infusion (83 microg/min) of metaraminol (Aramine) there was improvement in his blood pressure, cardiac output and urine output.
CONCLUSIONS: This is the first case report of the beneficial use of metaraminol (aramine) in the management of significant amlodipine poisoning unresponsive to conventional therapy.

Language: en

Keywords

Adrenergic alpha-Agonists; Adult; Amlodipine; Calcium Channel Blockers; Drug Overdose; Hemodynamics; Humans; Infusions, Intravenous; Male; Metaraminol; Suicide, Attempted