Citation

Siegert RJ, Abernethy DA. J. Neurol. Neurosurg. Psychiatry 2005; 76(4): 469-475.

Copyright

(Copyright © 2005, BMJ Publishing Group)

DOI

10.1136/jnnp.2004.054635

PMID

15774430

PMCID

PMC1739575

Abstract

Several studies have reported high rates of depression in multiple sclerosis (MS) with a lifetime prevalence of approximately 50% and an annual prevalence of 20% not uncommon. Concern about the potential of new drug treatments to exacerbate or precipitate depression in MS has led to increased interest in the relation between MS and depression. This review on MS and depression identifies the following key issues: How common is depression in people with MS? Is depression in MS associated with lesions in specific regions of the central nervous system? Is there an increased risk of suicide in MS? Is there a higher than expected incidence of anxiety disorders in MS? Are fatigue and depressed mood related in MS? Is there a relation between depression and cognitive impairment in MS? Which psychosocial variables affect the development of depression in MS? Does treatment with interferon increase the risk of depression? How effective are treatments for MS patients with depression? Each of these issues is briefly reviewed with critical commentary, and some priorities for future research are suggested.

Language: en

Keywords

Adjuvants, Immunologic; Anxiety; Central Nervous System; Cognition Disorders; Comorbidity; Depression; Fatigue; Humans; Interferon beta-1a; Interferon-beta; Interview, Psychological; Magnetic Resonance Imaging; Multiple Sclerosis; Neuropsychological Tests; Prevalence; Risk Factors; Secondary Prevention; Suicide; Surveys and Questionnaires