Citation

Blayac D, Roch A, Michelet P, De Francheschi E, Auffray JP. Ann. Fr. Anesth. Reanim. 2004; 23(10): 1007-1010.

Copyright

(Copyright © 2004, Elsevier Publishing)

DOI

10.1016/j.annfar.2004.07.006

PMID

15501631

Abstract

A sixty-year-old woman was admitted in the ICU after Depamide (Valpromide) self-poisoning (430 mg/kg). Four hours after the ingestion, the patient presented coma (Glagow coma score of 3) with bilateral mydriasis requiring tracheal intubation and mechanical ventilation, hypotension requiring epinephrine infusion (0.9 microg/kg per minute), acidosis and hyperlactatemia (29.7 mmol/l at 12 hours) without any kidney or liver failure. The maximal serum valproic acid concentration measured was 342 mg/l after twelve hours (therapeutic rate: 35-85 mg/l). A continuous infusion of sodium bicarbonate was associated with continuous venovenous haemodiafiltration. Progressive haemodynamic improvement and neurologic recovery leaded to extubation at 36 hours.

Language: fr

Keywords

Anticonvulsants; Female; Glasgow Coma Scale; Hemodiafiltration; Humans; Infusions, Intravenous; Middle Aged; Sodium Bicarbonate; Suicide, Attempted; Treatment Outcome; Valproic Acid