Citation

Ullrich H, Passenberg P, Agelink MW. Dtsch. Med. Wochenschr. 2003; 128(48): 2534-2536.

Copyright

(Copyright © 2003, Georg Thieme Verlag)

DOI

10.1055/s-2003-44949

PMID

14648436

Abstract

HISTORY AND CLINICAL FINDINGS: A 43-year-old woman was admitted after a suicide attempt with 1.5 g atenolol. Physical and neurological examination showed no abnormality, but psychiatric examination revealed symptoms of a major depression. Four weeks prior to admission a valsartan-hydrochlorothiazide combination had been added to the antihypertensive medication.
INVESTIGATIONS: Laboratory tests, electrocardiography, chest-x-ray, electroencephalography and cranial computerised tomography showed no abnormality.
DIAGNOSIS AND COURSE: The depressive disorder resolved within ten days after discontinuation of valsartan and hydrochlorothiazide without specific treatment. Blood pressure was normal under treatment with metoprolol.
CONCLUSION: Depressive drug reactions can produce a substantial morbidity. This case of a drug induced affective disorder should heighten the awareness of unusual reactions to valsartan-hydrochlorothiazide therapy.

Language: de

Keywords

Adult; Antihypertensive Agents; Depression; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Suicide, Attempted; Tetrazoles; Valine; Valsartan