Citation

Sbei M, Campellone JV. Epilepsia 2001; 42(8): 1082-1083.

Copyright

(Copyright © 2001, John Wiley and Sons)

DOI

10.1046/j.1528-1157.2001.0420081082.x

PMID

11554897

Abstract

PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.
RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.

Language: en

Keywords

Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle Aged; Neurotoxicity Syndromes; Suicide, Attempted; Triazines; Valproic Acid