Citation

Smesny S, Volz HP, Liepert J, Tauber R, Hochstetter A, Sauer H. Nervenarzt, Der 2001; 72(9): 734-738.

Copyright

(Copyright © 2001, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s001150170054

PMID

11572108

Abstract

We report on a patient with therapy-resistant major depression according to DSM-IV criteria who has been hospitalized for 60 months during the last 7 years. Not even five electroconvulsive therapy (ECT) series (61 single applications) brought lasting remission of symptoms. As cognitive deficits developed and prolonged postnarcotic recovery times were observed, further ECT was contraindicated. The left frontal cortex was chosen as the target site for repetitive transcranial magnetic stimulation (rTMS) treatment. For identification, a neuronavigational system was used that allows online monitoring of the position of the magnetic coil in relation to the individual cortex. The therapeutic progress was monitored by standardized psychiatric ratings (HAMD, BDI). In addition, cognitive performance was tested during the course of treatment. Only a few rTMS applications already caused an obvious brightening in mood, remission of depressive delusional symptoms, and an increase in personal interests and activities. After 4 weeks of daily treatment, the patient was discharged from the ward. The rTMS treatments and psychotherapeutic counseling have been continued on an outpatient basis. Thus, pharmaco- and psychotherapeutic interventions combined with rTMS led to persistent symptom remission and social reintegration.

Language: de

Keywords

Adult; Ambulatory Care; Combined Modality Therapy; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Humans; Psychotherapy; Psychotropic Drugs; Secondary Prevention; Self-Injurious Behavior; Suicide, Attempted; Transcranial Magnetic Stimulation; Treatment Outcome