Citation

Catalano G, Catalano MC, Epstein MA, Tsambiras PE. Clin. Neuropharmacol. 2001; 24(3): 158-162.

Copyright

(Copyright © 2001, Lippincott Williams and Wilkins)

DOI

10.1097/00002826-200105000-00007

PMID

11391127

Abstract

Citalopram is a member of the selective serotonin reuptake inhibitor class of antidepressants. In 1998, citalopram was approved by the US Food and Drug Administration for the treatment of major depression. Like the other selective serotonin reuptake inhibitors, citalopram enjoys a relatively benign side effect profile compared with the tricyclic antidepressants and the monoamine oxidase inhibitors. However, citalopram has been associated with electrocardiographic changes and seizures at doses greater than 600 mg per day. Fatalities have occurred with citalopram-only overdoses. We report the case of a healthy 21-year-old woman who developed QTc interval prolongation after ingestion of approximately 400 mg citalopram. We discuss the cardiac effects of citalopram, review previous cases of citalopram overdose, and discuss treatment recommendations.

Language: en

Keywords

Adult; Citalopram; Electrocardiography; Female; Humans; Long QT Syndrome; Respiratory Mechanics; Selective Serotonin Reuptake Inhibitors; Suicide, Attempted