Citation

Bédry R, Deschamps L, Pehourcq F, Moore N, Pillet O, Favarel-Garrigues JC. Vet. Hum. Toxico. 1999; 41(1): 20-22.

Copyright

(Copyright © 1999, American College of Veterinary Toxicologists)

DOI

unavailable

PMID

9949479

Abstract

A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated.

Language: en

Keywords

Adult; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clozapine; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Male; Schizophrenia; Treatment Outcome