Citation

Caberlotto L, Hurd YL. Neuroreport 1999; 10(8): 1747-1750.

Copyright

(Copyright © 1999, Lippincott Williams and Wilkins)

DOI

10.1097/00001756-199906030-00022

PMID

10501568

Abstract

In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.

Language: en

Keywords

Adult; Aged; Autoradiography; Bipolar Disorder; Depressive Disorder; Female; Humans; In Situ Hybridization; Male; Middle Aged; Neuropeptide Y; Prefrontal Cortex; RNA, Messenger; Schizophrenia; Statistics, Nonparametric