Citation

Normann C, Hesslinger B, Frauenknecht S, Berger M, Walden J. Pharmacopsychiatry 1997; 30(6): 263-265.

Copyright

(Copyright © 1997, Georg Thieme Verlag)

DOI

10.1055/s-2007-979504

PMID

9442549

Abstract

We report the case of a patient developing psychosis after the addition of mirtazapine, a novel antidepressant enhancing serotonergic neurotransmission, to a chronic levodopa regimen. There was complete and rapid recovery upon low-dose clozapine treatment. To our knowledge, this is the first published case of a mirtazapine-levodopa interaction and the second case report of a psychosis induced by a serotonergic antidepressant in a patient with Parkinson's disease (PD). This phenomenon might be due to a postsynaptic serotonin receptor supersensitization caused by low central serotonin levels in treated PD.

Language: en

Keywords

Adult; Antidepressive Agents, Tricyclic; Antiparkinson Agents; Depressive Disorder; Drug Interactions; Female; Humans; Levodopa; Mianserin; Mirtazapine; Parkinson Disease; Psychoses, Substance-Induced; Suicide, Attempted