Citation

Rochet T, Tonon MC, Kopp N, Vaudry H, Miachon S. Neuroreport 1998; 9(1): 53-56.

Copyright

(Copyright © 1998, Lippincott Williams and Wilkins)

DOI

10.1097/00001756-199801050-00011

PMID

9592047

Abstract

Diazepam-binding inhibitor (DBI) and its processing products, including the octadecaneuropeptide (ODN), are polypeptides called endozepines which have multiple biological effects, including regulation of mitochondrial steroidogenesis and modulation of GABA-gated chloride channels. Concentrations of ODN-like immunoreactivity (ODN-Li) were measured by radioimmunoassay in the frontal cortex of nine drug-free suicides and nine drug-free sudden-death victims. The level of ODN-Li was higher in the right than in the left frontal cortex, in both suicide (p < 0.05) and control (p < 0.02) subjects. No significant differences were found between suicides and controls either in the right and left cortex, or when considering the gender and the post-mortem diagnosis of depression.

Language: en

Keywords

Adult; Carrier Proteins; Case-Control Studies; Diazepam Binding Inhibitor; Evaluation Studies as Topic; Female; Frontal Lobe; Humans; Male; Middle Aged; Neuropeptides; Peptide Fragments; Radioimmunoassay; Statistics, Nonparametric; Steroids; Suicide