Citation

Scott TF, Allen D, Price TR, McConnell H, Lang D. J. Neuropsychiatry Clin. Neurosci. 1996; 8(3): 318-323.

Copyright

(Copyright © 1996, American Neuropsychiatric Association, Publisher American Psychiatric Publishing)

DOI

10.1176/jnp.8.3.318

PMID

8854304

Abstract

Retrospective review of affective disturbances in 238 patients with multiple sclerosis (MS) seen over a 6-month period revealed: 1) 51 patients (22%) received pharmacologic treatment for depressive symptoms during or within 4 years of the study period, and 17 (7%) received treatment for rapid mood swings; 2) among the 51 depressed patients, response rate to medication was extremely high; 3) relapse of depressive symptomatology after discontinuation of medication was also high (17/29); 4) first episodes of major depression frequently occurred during periods of MS progression or exacerbation, but first episodes also occurred during periods of relative clinical stability; 5) suicidal ideation was common (12 patients), but only 1 patient had a history of attempted suicide; and 6) side effects were tolerable in most patients.

Language: en

Keywords

Adult; Affect; Antidepressive Agents; Depressive Disorder; Drug Resistance; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Psychiatric Status Rating Scales; Retrospective Studies