Citation

Naylor L, Dean B, Opeskin K, Pavey G, Hill C, Keks N, Copolov D. J. Neural. Transm. 1996; 103(6): 749-757.

Copyright

(Copyright © 1996, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/BF01271234

PMID

8836936

Abstract

[3H]paroxetine binding to membrane from hippocampus, obtained at autopsy, from 24 schizophrenic and 24 non-schizophrenic subjects has been measured. The affinity of [3H]paroxetine binding to hippocampal membrane was decreased in subjects with schizophrenia (Kd = 0.50 +/- 0.04 vs. 0.24 +/- 0.02nM; mean +/- S.E.M. p < 0.001) but was not different in schizophrenic subjects who had or had not committed suicide (Kd = 0.50 +/- 0.07 vs. 0.50 +/- 0.04nM). The density of [3H]paroxetine binding sites did not differ between the schizophrenic and non-schizophrenic subjects. For the schizophrenic subjects, there was no relationship between ante-mortem neuroleptic drug treatment and [3H]paroxetine binding to the hippocampal membrane. Finally, this study has shown that neuroleptic drug treatment of rats does not alter [3H]paroxetine binding to the hippocampal membranes. Thus, it would seem that the changes in the affinity of [3H]paroxetine binding to the hippocampus of schizophrenic subjects are not likely to be due to neuroleptic drug treatment but may be involved in the pathology of the illness.

Language: en

Keywords

Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Binding, Competitive; Carrier Proteins; Female; Haloperidol; Hippocampus; Humans; Male; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Suicide; Tritium