Citation

Broxterman HJG, Liskamp RMJ. Recueil des Travaux Chimiques des Pays‐Bas 1991; 110(2): 46-52.

Copyright

(Copyright © 1991)

DOI

10.1002/recl.19911100204

PMID

unavailable

Abstract

Serine and threonine analogues (compounds 2‐6) are readily accessible by reaction of the anion of N,N‐dibenzylglycine ethyl ester (1) with an appropriate carbonyl compound. These analogues will be incorporated into Protein Kinase C (PKC) substrates. The serine aldehyde derivative 7 was used for the preparation of the corresponding diethyl acetal 9. This compound was the starting material in the synthesis of the suicide precursor 8, featuring a reductive amination leading to 12 and a Lewis‐acid‐catalysed cyclization giving 8. Copyright © 1991 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

Language: en