Citation

García MR, Ryan ND, Rabinovitch H, Ambrosini P, Twomey J, Iyengar S, Novacenko H, Nelson B, Puig-Antich J. J. Am. Acad. Child Adolesc. Psychiatry 1991; 30(3): 398-406.

Copyright

(Copyright © 1991, American Academy of Child Adolescent Psychiatry, Publisher Lippincott Williams and Wilkins)

DOI

10.1097/00004583-199105000-00008

PMID

1905294

Abstract

In an effort to evaluate whether differences exist in the hypothalamic-pituitary-thyroid axis of depressed children, a thyrotropin releasing hormone (TRH) stimulation test was administered to 55 prepubertal subjects who were divided into three groups matched for age and sex: a depressed group (endogenous N = 15, nonendogenous N = 15), a psychiatric nondepressed control group (N = 16), and a normal control group (N = 9). Each subject was tested at two dosages of TRH, 2 micrograms/kg and 7 micrograms/kg. Increasing age and female sex were positively correlated with a greater thyroid stimulating hormone (TSH) response. TSH response to TRH was examined with subjects reclassified by severe suicidal ideation, severe aggression, and parental history of alcoholism.

RESULTS of this study are contrasted with the adult psychiatric literature.

Language: en

Keywords

Age Factors; Aggression; Child; Depressive Disorder; Female; Humans; Male; Sex Factors; Suicide; Thyrotropin; Thyrotropin-Releasing Hormone