Citation

Besser R. EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte Geb. 1991; 22(1): 37-39.

Copyright

(Copyright © 1991, Georg Thieme Verlag)

DOI

unavailable

PMID

1650695

Abstract

A patient with severe organophosphate intoxication received Neostigmine 1 mg IV during the intermediate syndrome. This dose resulted clinically and neurophysiologically in a marked deterioration of neuro-muscular transmission. This effect of neostigmine on the neuromuscular block during the intermediate syndrome (deterioration) differs from its effect on a similar pattern (improvement), which is seen in the delayed neuropathy following organophosphate exposure. The administration of therapeutic doses of cholinesterase inhibitors in patients with a reduced safety margin due to inhibition of endplate acetylcholinesterase may be dangerous.

Language: de

Keywords

Aged; Humans; Male; Motor Endplate; Neostigmine; Neuromuscular Junction; Organophosphate Poisoning; Suicide, Attempted; Synaptic Transmission