Citation

Varon J, Duncan SR. Ann. Emerg. Med. 1991; 20(10): 1125-1127.

Copyright

(Copyright © 1991, American College of Emergency Physicians, Publisher Elsevier Publishing)

DOI

10.1016/s0196-0644(05)81389-7

PMID

1928887

Abstract

The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors may be mediated by the endogenous opioid system. The opioid antagonist naloxone has been shown to block or reverse the hypotensive actions of captopril. We report a case of an intentional captopril overdose, manifested by marked hypotension, that resolved promptly with the administration of naloxone. To our knowledge, this is the first reported case of captopril-induced hypotension treated with naloxone. Our experience demonstrates a possible role of naloxone in the reversal of hypotension resulting from captopril.

Language: en

Keywords

Adult; Blood Pressure; Captopril; Drug Overdose; Female; Humans; Hypotension; Naloxone; Suicide, Attempted