Citation

Kudo K, Nagata T, Imamura T, Kage S, Hida Y. Int. J. Legal Med. 1991; 104(2): 67-69.

Copyright

(Copyright © 1991, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/BF01626033

PMID

2054306

Abstract

A reliable and sensitive method has been developed to assess the concentrations of the hypnotic drug triazolam in human tissues, including putrefied tissues. The method involves a 3-step solvent extraction, clean-up on a silica gel column and gas chromatography using a nitrogen phosphorus detector and a capillary column. Estazolam was used as an internal standard. The calibration curve was linear over the concentration range 1 ng/g-1 microgram/g and the lower limit of detection was 0.5 ng/g. A forensic study was performed on the toxicological effects of triazolam using putrefied tissues.

Language: en

Keywords

Adult; Chromatography, Gas; Drug Overdose; Humans; Liver; Male; Postmortem Changes; Suicide; Tissue Distribution; Triazolam