Citation

Crompton DR, Pegg SP, Jellett LB, Middleton W. Aust. N. Zeal. J. Psychiatry 1991; 25(3): 419-421.

Copyright

(Copyright © 1991, Royal Australian and New Zealand College of Psychiatrists, Publisher SAGE Publishing)

DOI

10.3109/00048679109062645

PMID

1958167

Abstract

A case of self-inflicted burns which occurred in the setting of a major depression with psychotic features is described. The case emphasises the difficulties in utilising plasma (serum) tricyclic antidepressant levels to determine adequacy of treatment and risk of toxicity. The case discussion demonstrates the altered pharmacokinetics of tricyclic antidepressants that can occur during disorders such as burns, surgery and medical illness.

Language: en

Keywords

Adult; Amitriptyline; Burns; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Nortriptyline; Serum Albumin; Suicide, Attempted