Citation

Lechleitner P, Dzien A, Haring C, Glossmann H. Toxicology 1990; 64(3): 325-329.

Copyright

(Copyright © 1990, Elsevier Publishing)

DOI

10.1016/0300-483x(90)90124-y

PMID

2148447

Abstract

A 43-year-old patient with mild heart failure attempted suicide by ingesting between 5000 and 7500 mg of captopril. Blood pressure oscillated around 100-120/50-75 mmHg and pulse rate showed no tendency to accelerate (75-100/min). The psychiatric examination showed no drug induced psychopathological symptoms. The calculated half-life of captopril was 4.4 h. Seven hours after ingestion of approximately 50 times the maximal therapeutic daily dose of captopril the serum concentration reached 20 micrograms/ml. The calculated amount of absorbed captopril was approximately 5400 mg. Atrial natriuretic factor (ANF) plasma levels were slightly elevated and showed no tendency to increase or to fall.

Language: en

Keywords

Adult; Atrial Natriuretic Factor; Blood Pressure; Captopril; Half-Life; Humans; Male; Substance-Related Disorders; Suicide, Attempted