Citation

Dirks E, Gieshoff B, Stahlmann R, Wehr M, Hager W. Z. Kardiol. 1990; 79(1): 54-59.

Copyright

(Copyright © 1990, Steinkopff)

DOI

unavailable

PMID

2107645

Abstract

After suicidal ingestion of 3 g flecainide a 34-year-old woman showed somnolence, cerebral convulsion, disturbances of atrioventricular and intraventricular conduction and ventricular asystole. The maximum flecainide plasma level was 4900 ng/ml; this level is extremely high and exceeds the maximum therapeutic level by five times. After initial cardiopulmonary resuscitation and stabilization by intensive care treatment we performed a combined hemodialysis/hemoperfusion therapy (with activated charcoal). This procedure led to a rapid decrease of flecainide plasma levels and simultaneous improvement of ECG-alterations. The initial decrease in flecainide plasma levels during extracorporeal elimination occurred much quicker (4.5-8.5 h plasma halflife) than the spontaneous decrease rate of flecainide in humans (12-20 h plasma half-life). We conclude that, perhaps, hemodialysis/hemoperfusion therapy is an efficient method for decreasing toxic plasma levels of flecainide and for improvement of the clinical course of this intoxication.

Language: de

Keywords

Adult; Drug Overdose; Electrocardiography; Female; Flecainide; Heart Arrest; Hemoperfusion; Humans; Renal Dialysis; Suicide, Attempted