Citation

Anderson GM, Segman RH, King RA. Isr. J. Psychiatry Relat. Sci. 1995; 32(1): 44-50.

Copyright

(Copyright © 1995, Israel Psychiatric Association, Publisher Israel Science Publishers)

DOI

unavailable

PMID

7622346

Abstract

Despite the demonstrated anti-depressant efficacy of the selective serotonin reuptake inhibitors (SSRIs), increased suicidal ideation and/or agitation have been reported in a small proportion of individuals receiving fluoxetine or other SSRIs. Part II of this review examines fluoxetine's acute effects on serotonergic functioning. Although acute fluoxetine administration produces a short-term compensatory decrease in the firing of 5-HT neurons, the neurobiological data reviewed suggests that this decrease probably does not lead to an over-compensatory net decrease in 5-HT functioning. The implications of fluoxetine's complex effects on the 5-HT systems are discussed with respect to clinical practices and future research.

Language: en

Keywords

Animals; Brain; Fluoxetine; Humans; Receptors, Serotonin; Risk Factors; Serotonin; Suicide; Synaptic Transmission