Citation

Aubin S, Lorette G, Müller C, Vaillant L. Clin. Exp. Dermatol. 1995; 20(4): 348-350.

Copyright

(Copyright © 1995, John Wiley and Sons)

DOI

10.1111/j.1365-2230.1995.tb01341.x

PMID

8548998

Abstract

We report a case of acute intoxication due to a massive overdose of isotretinoin. A 29-year-old male patient ingested 900 mg of isotretinoin corresponding to 12.5 mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously, We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side-effects were mild and represented only exacerbations of some common isotretinoin side-effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotretinoin overdose.

Language: en

Keywords

Adult; Drug Overdose; Humans; Isotretinoin; Keratolytic Agents; Male; Suicide, Attempted