Citation

Liu F, Liu YT, Feng CL, Luo Y. Yao Xue Xue Bao 1994; 29(8): 610-616.

Copyright

(Copyright © 1994, Zhongguo yao xue hui)

DOI

unavailable

PMID

7985519

Abstract

A systematic procedure for the determination of methaqualone and its metabolites in blood and urine by UV spectrophotometry, GC and GC/MS was developed. Urine and blood samples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase and liquid-liquid extractions were used in the extraction and clean-up of the samples. The total amount of methaqualone and its metabolites was measured by UV spectrophotometry. The amount of parent methaqualone was quantitated by GC/FID. Methaqualone and its 10 metabolites including two acetyl metabolites were found in urine and blood. This procedure is useful for monitoring drugs in emergency treatment.

Language: en

Keywords

Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Humans; Lung Neoplasms; Methaqualone; Middle Aged; Spectrophotometry, Ultraviolet; Suicide, Attempted