Citation

Baischer W, Wagner A, Seidler D, Musalek M, Laggner A. Wien. Klin. Wochenschr. 1994; 106(1): 27-29.

Copyright

(Copyright © 1994, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

8135028

Abstract

A 43 year-old female patient with a history of manic-depressive illness and prophylactic carbamazepine (CBZ) medication ingested a potentially lethal overdose of 20 g of the substance. Neurotoxic symptoms reached full intensity after about 24 hours. Subsequently, the patient developed a gastrointestinal atony, which proved to be refractory to treatment for several days. Moreover, there was an increase of bilirubin. Parallel to this we observed the persistence-and even intermittent re-increase--of toxic serum CBZ concentrations for one week with corresponding protracted clinical symptomatology.

Language: de

Keywords

Adult; Bipolar Disorder; Carbamazepine; Chemical and Drug Induced Liver Injury; Coma; Drug Overdose; Female; Humans; Intestinal Pseudo-Obstruction; Metabolic Clearance Rate; Neurologic Examination; Peristalsis; Suicide, Attempted