Citation

Moore DF, Bentley AM, Dawling S, Hoare AM, Henry JA. J. Toxicol. Clin. Toxicol. 1994; 32(2): 199-204.

Copyright

(Copyright © 1994, Marcel Dekker)

DOI

10.3109/15563659409000451

PMID

8145360

Abstract

Ingestion of over 60 g of formic acid by an adult is potentially fatal. We report a case of a 36-year-old woman with a history of depression who ingested 110 g of formic acid. She survived a complicated intensive care hospitalization following usage of intravenous folinic acid, urinary alkalinization, intravenous furosemide and supportive care. We suggest a management protocol aimed at minimizing formate toxicity by enhancing hepatic formate degradation via the folinic acid 'one carbon pool' and by enhanced renal elimination of formate.

Language: en

Keywords

Adult; Female; Formates; Furosemide; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Kidney; Leucovorin; Poisoning; Suicide, Attempted