Citation

McIntyre IM, King CV, Cordner SM, Drummer OH. J. Forensic Sci. 1994; 39(2): 486-493.

Copyright

(Copyright © 1994, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

unavailable

PMID

8195760

Abstract

Postmortem blood and liver concentrations of clomipramine were determined in ten cases by high performance liquid chromatography (HPLC). Blood concentrations ranged from 0.21 to 4.9 mg/L, and liver concentrations from 7.0 to 320 mg/kg. Two cases associated with clomipramine toxicity were clearly differentiated from other cases by the analysis of liver. The concentrations of clomipramine in these two cases were 3.3 and 1.8 mg/L in blood, and 280 and 320 mg/kg in liver. The liver concentrations were 10 to 30 fold greater in the deaths associated with drug toxicity compared with the other cases. One case, where cardiac blood was collected in place of femoral blood, showed a high blood concentration (4.9 mg/L), but an arguably therapeutic liver concentration (13 mg/kg). The analysis of femoral blood together with liver provides the best guide as to the significance of post-mortem clomipramine concentrations.

Language: en

Keywords

Adult; Aged; Chromatography, High Pressure Liquid; Clomipramine; Fatal Outcome; Female; Forensic Medicine; Humans; Liver; Male; Middle Aged; Poisoning; Postmortem Changes; Suicide