Citation

Jortani SA, Valentour JC, Poklis A. Forensic Sci. Int. 1994; 64(2-3): 165-170.

Copyright

(Copyright © 1994, Elsevier Publishing)

DOI

10.1016/0379-0738(94)90227-5

PMID

8175087

Abstract

Enantiomers of thioridazine (TRZ) were determined in postmortem tissues obtained from a patient on chronic TRZ therapy by sequential achiral and chiral high pressure liquid chromatography. Tissue concentrations of (+)-TRZ found in liver, brain, bile and blood were: 6.46, 0.40, 0.48 and 0.07 mg/l or mg/kg, respectively. Concentrations of (-)-TRZ in liver, brain, bile and blood were: 12.2, 0.81, 1.07 and 0.20 mg/l or mg/kg, respectively. These data demonstrate the stereoselective disposition of TRZ in human tissues.

Language: en

Keywords

Adult; Body Fluids; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Fluoxetine; Humans; Liver; Postmortem Changes; Suicide; Thioridazine