Citation

Möller HJ, Steinmeyer EM. Eur. Neuropsychopharmacol. 1994; 4(1): 55-59.

Copyright

(Copyright © 1994, Elsevier Publishing)

DOI

10.1016/0924-977x(94)90315-8

PMID

8204997

Abstract

There is some empirical evidence that selective serotonin reuptake inhibitors reduce suicidal ideas faster than other antidepressants. These findings are well in line with the theory of a serotonergic hypofunction in suicidal patients. To test this hypothesis the data of a 6-week double-blind control-group study comparing paroxetine versus amitriptyline were analyzed with respect to suicidality. The global antidepressive efficacy was comparable under dosages of 30 mg paroxetine or 150 mg amitriptyline per day. A differentiated analysis failed to confirm the hypothesis of a faster reduction of suicidal cognitions by paroxetine.

Language: en

Keywords

Adult; Depressive Disorder; Double-Blind Method; Humans; Paroxetine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Suicide