Citation

Fasching P, Roden M, Stühlinger HG, Kurzemann S, Zeiner A, Waldhäusl W, Laggner AN. Diabet. Med. 1994; 11(3): 323-325.

Copyright

(Copyright © 1994, Diabetes UK, Publisher John Wiley and Sons)

DOI

10.1111/j.1464-5491.1994.tb00279.x

PMID

8033534

Abstract

A well-documented case of a 35-year-old male Type 1 diabetic patient who was admitted as an emergency after having injected 1500 international units (IU) of insulin (750 IU regular insulin,750 IU NPH-insulin) subcutaneously as a suicidal attempt is reported. Computing disappearance rates of glucose from its infused amounts necessary to maintain euglycaemia during 65 h after the insulin injection in analogy to experimental hyperinsulinaemic euglycaemic clamp examinations, a glucose consumption of 55.6 mumol kg-1 min-1 was found at peak serum insulin concentrations of about 14,400 pmol l-1. The insulin-induced glucose dynamics resemble closely those seen in healthy persons and Type 1 diabetic subjects during a 10 mU kg-1 min-1 euglycaemic clamp. This information may be useful in the handling of similar cases of insulin intoxication.

Language: en

Keywords

Adult; Bipolar Disorder; Blood Glucose; Diabetes Mellitus, Type 1; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin, Isophane; Male; Suicide, Attempted; Time Factors