Citation

Roberge RJ, Martin TG. Ann. Emerg. Med. 1994; 23(3): 586-590.

Copyright

(Copyright © 1994, American College of Emergency Physicians, Publisher Elsevier Publishing)

DOI

10.1016/s0196-0644(94)70083-4

PMID

8135440

Abstract

A 19-year-old man who attempted suicide by ingesting approximately 600 mg fluoxetine (Prozac) and 140 mg loxapine (Loxitane) had two episodes of atrial flutter shortly thereafter. Admission serum fluoxetine, norfluoxetine, and loxapine levels were 1,053 ng/mL, 702 ng/mL, and 40 ng/mL, respectively. This case of atrial flutter in association with an overdose of either of these drugs demonstrates the potential for cardiotoxicity with these agents in the overdose setting. Theoretical mechanisms of cardiotoxicity are presented.

Language: en

Keywords

Adult; Atrial Flutter; Drug Overdose; Fluoxetine; Humans; Loxapine; Male; Suicide, Attempted