Citation

Kleinschmidt S, Kramer T, Ziegenfuss T. Anasthesiol. Intensivmed. Notfallmed. Schmerzther. 1994; 29(4): 248-251.

Copyright

(Copyright © 1994, Georg Thieme Verlag)

DOI

10.1055/s-2007-996731

PMID

7981355

Abstract

We report on a 52-year old woman who had taken an unknown dose of the organophosphate insecticide Metasystox R with suicidal intention. Ingestion was followed by cardio-respiratory failure. After successful cardio-pulmonary resuscitation, main therapeutic principles were the immediate application of atropine and decontamination procedures such as gastric lavage, induction of diarrhoea and instillation of carbon. A single combined haemoperfusion and haemodialysis treatment was performed as a secondary elimination technique. After rapid toxicological analysis, obidoxime was administered as a supplementary antidote. After 14 days of treatment, the patient could leave the ICU with a complete restitution.
CONCLUSION: Our case report demonstrates the efficiency of immediate application of antidotal therapy (atropine), decontamination and elimination techniques even in case of cardio- respiratory failure after organophosphate poisoning. Toxicological analysis will be beneficial for diagnosis and the indication of further treatment with obidoxime.

Language: de

Keywords

Atropine; Critical Care; Drug Overdose; Female; Heart Arrest; Humans; Insecticides; Metabolic Clearance Rate; Middle Aged; Organothiophosphorus Compounds; Suicide, Attempted