Citation

Kintz P, Flesch F, Jaeger A, Mangin P. J. Pharm. Biomed. Anal. 1993; 11(4-5): 335-338.

Copyright

(Copyright © 1993, Elsevier Publishing)

DOI

10.1016/0731-7085(93)80025-v

PMID

8357869

Abstract

A sensitive and specific quantitative method for the determination of zipeprol, a newly abused antitussive, in human fluids is described. Zipeprol and an internal standard, levallorphan, are isolated by a basic extraction and back-extraction process. The final extract is derivatizated with BSTFA + 1% TMCS and separated on a 12-m HP-1 capillary column. Drugs are detected by selected ion monitoring at m/z 335 and m/z 355 for zipeprol and the internal standard, respectively. The minimum detectable quantities are 0.6 and 0.4 ng ml-1, for zipeprol in plasma and urine, respectively. Relative standard deviations for within-run data are less than 6%.

Language: en

Keywords

Adult; Antitussive Agents; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Humans; Indicators and Reagents; Levallorphan; Male; Piperazines; Solvents; Suicide, Attempted