Citation

Worm K, Kringsholm B, Steentoft A. Int. J. Legal Med. 1993; 106(3): 115-118.

Copyright

(Copyright © 1993, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/BF01225229

PMID

8117587

Abstract

The neuroleptic drug clozapine is used in the treatment of schizophrenia and is characterized by not having the extrapyramidal side-effects usually shown by neuroleptics. Unfortunately clozapine has other side-effects, which limit its use. This study presents methods for the analysis of clozapine and desmethylclozapine in whole blood and tissue. Case histories and pathology findings are described for 3 autopsy cases with fatal concentrations of clozapine, 5 with toxic concentrations and 2 with therapeutic concentrations together with the concentrations found in a living person.

Language: en

Keywords

Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Clozapine; Drug Overdose; Fatal Outcome; Female; Forensic Medicine; Humans; Liver; Male; Middle Aged; Muscles; Suicide