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Journal Article

Citation

Judd FK, Moore K, Norman TR, Burrows GD, Gupta RK, Parker G. Aust. N. Zeal. J. Psychiatry 1993; 27(1): 49-55.

Copyright

(Copyright © 1993, Royal Australian and New Zealand College of Psychiatrists, Publisher SAGE Publishing)

DOI

10.3109/00048679309072123

PMID

8481170

Abstract

The antidepressant efficacy and side effect profile of a fixed dose of 20 mg/day of fluoxetine, a specific serotonin reuptake inhibitor, were compared to those of amitriptyline. Fifty-eight patients with DSM-III-R depression were randomly assigned to receive either fluoxetine or amitriptyline. Fifty-six patients (fluoxetine N = 23, amitriptyline N = 23) completed the 6 week study. Comparable antidepressant efficacy was demonstrated for the two drugs. Patients taking fluoxetine reported less side-effects than those taking amitriptyline.


Language: en

Keywords

Adult; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Personality Inventory; Suicide; Suicide Prevention

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