Citation

Harrison MB, Wiley RG, Wooten GF. Brain Res. 1992; 596(1-2): 330-336.

Copyright

(Copyright © 1992, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

10.1016/0006-8993(92)91567-x

PMID

1334779

Abstract

The suicide transport agent volkensin was used to produce a selective lesion of striatonigral projection neurons and the time course of changes in binding at striatal D1 and D2 receptors analyzed. Both show a time-dependent decrease with two-thirds of the total change occurring within the first 10 days and a greater decrease in D1 receptor density at all time points. Our results confirm selective localization of D1 receptors to striatonigral neurons and are consistent with localization of some striatal D2 receptors to striatonigral neurons.

Language: en

Keywords

Animals; Autoradiography; Binding Sites; Corpus Striatum; Glycoproteins; Male; N-Glycosyl Hydrolases; Neurons; Plant Lectins; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Regression Analysis; Ribosome Inactivating Proteins, Type 2; Substantia Nigra; Synaptic Transmission; Time Factors