Citation

Katz R, Chuang LC, Sutton JD. Ann. Pharmacother. 1992; 26(9): 1087-1088.

Copyright

(Copyright © 1992, Harvey Whitney Books)

DOI

10.1177/106002809202600907

PMID

1384817

Abstract

OBJECTIVE: To report a case of pancytopenia following colchicine overdose and to discuss the use of granulocyte colony-stimulating factor (G-CSF) for treating this severe complication.
CASE SUMMARY: A 19-year-old man developed pancytopenia four days after ingestion of approximately 50-60 0.6-mg colchicine tablets in a suicide attempt. His pancytopenia resolved after subcutaneous administration of one 300-micrograms dose of G-CSF. The patient recovered from his other multiorgan disturbances during his hospitalization and was discharged from the hospital with elevated liver enzyme concentrations.
CONCLUSIONS: Colchicine overdose is rare, but can be fatal. The use of G-CSF appears to be beneficial in alleviating bone marrow depression in colchicine overdose situations.

Language: en

Keywords

Adult; Colchicine; Drug Overdose; Granulocyte Colony-Stimulating Factor; Humans; Male; Pancytopenia; Suicide, Attempted