Citation

Royer-Morrot MJ, Rambourg M, Jacob I, Bauer P, Royer RJ. J. Chromatogr. 1992; 581(2): 297-299.

Copyright

(Copyright © 1992, Elsevier Publishing)

DOI

10.1016/0378-4347(92)80286-y

PMID

1452623

Abstract

A reversed-phase liquid chromatographic method with ultraviolet detection for the determination of zopiclone in plasma is described. It is rapid, sensitive, reproducible and linear over a wide range. The method was used to study plasma zopiclone concentrations in a case of acute intoxication after oral ingestion of 300 mg of the drug. The plasma level was 1600 ng/ml 4.5 h after the dose and the elimination half-life was 3.5 h.

Language: en

Keywords

Adult; Azabicyclo Compounds; Chromatography, Liquid; Humans; Male; Piperazines; Reproducibility of Results; Spectrophotometry, Ultraviolet; Suicide, Attempted